Lack of stem cells may be the key to recurrent miscarriage
A new study suggests that the lack of stem cells in the uterine wall may lead
to recurrent miscarriage.
"We have found that there are certain defects in the uterine wall of patients with recurrent spontaneous abortion," said Jan Brosens, leader of the research team, who is a professor of obstetrics and gynaecology at Warwick University.
“It is conceivable that we can achieve the desire to become pregnant by correcting these defects in patients. In fact, this may be the only way to prevent miscarriage in this situation,” Brosens said at a university press conference.
15% to 25% of pregnancies will end in miscarriage. Repeated abortion occurs in 1 of 100 mothers. Among them, the researchers point out that recurrent abortion means that three or more consecutive pregnancy ends in abortion.
At the same time, scientists say stem cells have the potential to differentiate into many different types of cells.
In the study, the team analyzed endometrial samples from 183 women. They found that women who experienced repeated abortions had a lack of stem cell tissue.
The researchers point out that the uterine wall has a self-renewal function every time it passes through the menstrual cycle, abortion or the baby's birth. A shortage of stem cells may accelerate the aging of the endometrium and increase the risk of miscarriage.
"We speculate that cultivating stem cells from women who have undergone repeated abortions can improve the state of the cells in the uterine wall to some extent, freeing them from the risk of recurrent miscarriage," Brosens said.
The research-related article was published in the March 7 issue of Stem Cells.
“Currently, the real challenge is to develop a program to increase endometrial stem cell function,” said Siobhan Quenby, a collaborator at the press conference, who is a professor of obstetrics.
“Starting in the spring of 2016, we will begin piloting new interventions to improve the endometrium,” she said.
Quenby said that researchers will start from two aspects. First, they will develop a new endometrial testing program to improve the risk of recurrent abortion in women. Second, finding effective drugs and other interventions, such as “smearing” a drug on the inner wall of the uterus, or increasing the success rate of embryo implantation by some means, may increase the number of endometrial stem cells. Quantity," Quenby said.
"We have found that there are certain defects in the uterine wall of patients with recurrent spontaneous abortion," said Jan Brosens, leader of the research team, who is a professor of obstetrics and gynaecology at Warwick University.
“It is conceivable that we can achieve the desire to become pregnant by correcting these defects in patients. In fact, this may be the only way to prevent miscarriage in this situation,” Brosens said at a university press conference.
15% to 25% of pregnancies will end in miscarriage. Repeated abortion occurs in 1 of 100 mothers. Among them, the researchers point out that recurrent abortion means that three or more consecutive pregnancy ends in abortion.
At the same time, scientists say stem cells have the potential to differentiate into many different types of cells.
In the study, the team analyzed endometrial samples from 183 women. They found that women who experienced repeated abortions had a lack of stem cell tissue.
The researchers point out that the uterine wall has a self-renewal function every time it passes through the menstrual cycle, abortion or the baby's birth. A shortage of stem cells may accelerate the aging of the endometrium and increase the risk of miscarriage.
"We speculate that cultivating stem cells from women who have undergone repeated abortions can improve the state of the cells in the uterine wall to some extent, freeing them from the risk of recurrent miscarriage," Brosens said.
The research-related article was published in the March 7 issue of Stem Cells.
“Currently, the real challenge is to develop a program to increase endometrial stem cell function,” said Siobhan Quenby, a collaborator at the press conference, who is a professor of obstetrics.
“Starting in the spring of 2016, we will begin piloting new interventions to improve the endometrium,” she said.
Quenby said that researchers will start from two aspects. First, they will develop a new endometrial testing program to improve the risk of recurrent abortion in women. Second, finding effective drugs and other interventions, such as “smearing” a drug on the inner wall of the uterus, or increasing the success rate of embryo implantation by some means, may increase the number of endometrial stem cells. Quantity," Quenby said.
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